I have my abilities bound to Q/E/F/C. Launching today after the update, these keybinds weren't triggering my abilities. This was only fixed by rebinding the keys.
The same thing happened with my item keybinds. I have these on alt+Q, alt+E, alt+F, alt+C. However, after rebinding these, they still didn't work. I suspect that is because left alt was default bound to 'extra info' with the most recent patch? Unbinding left alt from extra info and rebinding the item keys still didn't work, and I had to fall back to alternative keybinds.
The same thing happened with my item keybinds. I have these on alt+Q, alt+E, alt+F, alt+C. However, after rebinding these, they still didn't work. I suspect that is because left alt was default bound to 'extra info' with the most recent patch? Unbinding left alt from extra info and rebinding the item keys still didn't work, and I had to fall back to alternative keybinds.