Posting this as a Vyper issue, since is the most likely to be repeatable, along side with Warden (I assume).
On the Keybind menu, while using the option for hero specific hotkeys, Abilities that are targeted cast, like Vyper 2 ( Lethal Venom) have an extra drop down menu for option of Quick...
Will start stating I only tested for Vyper, as it is the only character I use that has this type of ability. But basically in the keybinds menu she has a specific box for her quickcast ability, and that box in particular seems to be the issue. That config wont save after a game restart. When...