If you close the buy menu too quickly before assigning an imbue or an item slot, the game will crash if you try to do so.
This is also brought up in this thread.
Furthermore, if you need to sell an item to make space but you close the menu too fast, it won't crash but it will softlock your...
can't click the sell or cancel buttons when those elements overlap with the abilities... ideally the Escape button should exit this menu
Using a regular 1920x1080 monitor, nothing changed about the UI settings, can provide more details if needed